Treponema pallidum mRNA-LNP vaccine candidate encoding TP0954 induces strongly protective immunity in rabbits

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Authors

Zhiyu Lu · Chinese Academy of Medical Sciences & Peking Union Medical College

Yizhou Lu · Second Affiliated Hospital of Nanjing Medical University

Di Liu · Second Affiliated Hospital of Nanjing Medical University

Fangzhi Du · Chinese Academy of Medical Sciences & Peking Union Medical College

Qingyun Wu · Chinese Academy of Medical Sciences & Peking Union Medical College

Guoyang Liao · Chinese Academy of Medical Sciences & Peking Union Medical College

Abstract

Therefore, we successfully constructed a novel mRNA vaccine targeting TP0954 for syphilis and found superior immune protective effects compared with TP0954 recombinant protein vaccine, further confirming that TP0954 is a promising vaccine candidate for syphilis.

Topics & Keywords

Syphilis Diagnosis and Treatment Virology and Viral Diseases Reproductive tract infections research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Immunology

Volume 17, pp. 1769155-1769155

DOI: 10.3389/fimmu.2026.1769155

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