A Double-blind Randomized Trial of Oral Chlorhexidine Gluconate for Treatment of Oral <i>Staphylococcus aureus</i> Colonization in Healthy Children

We found that a 7-day 0.12% chlorhexidine gluconate mouthwash regimen significantly reduced <i>S. aureus</i> oropharyngeal colonization compared with placebo. This difference persisted at day 29, suggesting that CHG mouthwash may be a promising adjunctive decolonization agent that may decrease the high SSTI recurrence risk in children.