A simple and highly sensitive LC-MS/MS bioanalytical method for phosphorodiamidate morpholino oligonucleotides in plasma

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Authors

Tsubasa Kameyama · Nippon Shinyaku (Japan)

Shunji Imai · Nippon Shinyaku (Japan)

Rei Mitamura · Nippon Shinyaku (Japan)

Makoto Niwa · Nippon Shinyaku (Japan)

Tetsuhiro Yamada · Nippon Shinyaku (Japan)

Kazutomi Kusano · Nippon Shinyaku (Japan)

Abstract

A simple and highly sensitive bioanalytical method for the determination of viltolarsen was established by optimizing RPLC and PPT, and the method was successfully applied to a phosphorodiamidate morpholino oligomers with a different sequence.

Topics & Keywords

Acute Myeloid Leukemia Research Pesticide Residue Analysis and Safety Advanced Proteomics Techniques and Applications

Publication Details

Published in: Bioanalysis

Volume 18, Issue 2, pp. 133-145

DOI: 10.1080/17576180.2026.2632688

Field-Weighted Citation Impact: 0.00

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A simple and highly sensitive LC-MS/MS bioanalytical method for phosphorodiamidate morpholino oligonucleotides in plasma

Authors

Abstract

Topics & Keywords

Publication Details