Clinical Determinants of Early Achievement of the Therapeutic Teicoplanin Trough Concentration Range in Adult Cancer Patients

The fixed high-dose loading regimen of teicoplanin evaluated in this study achieves a day 4 trough concentration of 20 to 30 mg/L in about half of adult cancer patients. Higher body weight, febrile neutropenia, and lower serum albumin may help identify patients who require intensified loading and early therapeutic drug monitoring.