Interaction Between miRNAs and 14‐3‐3 Proteins in Regulating Tumor Progression and Therapeutic Potentials

The 14-3-3 biomolecules are highly conserved acidic eukaryotic proteins responsible for many cellular pathways, including cell cycle regulation, cell migration, and gene transcription control. Dysregulation of these proteins has been linked to the onset or suppression of cancers. Explorative studies have shown the positive and negative correlations between 14 and 3-3 proteins and oncomiRs or tumor suppressor miRNAs in cancer cells and supportive tissues during tumorigenesis, tumor progression, and metastasis. Understanding the interactions between 14 and 3-3 proteins and various miRNAs is crucial in introducing these proteins as novel prognostic cancer biomarkers. Furthermore, understanding the tumor-associated biological functions of 14-3-3 family proteins and targeting their interaction with specific miRNAs or directly manipulating 14-3-3 proteins may reveal their potential for cancer treatment in the future, as discussed in this review.