Self-reported health history from 70,724 individuals reveals novel HLA associations with allergy and other frequently underreported conditions

Collectively, our findings demonstrate the value of integrating population-scale, high-resolution <i>HLA</i> genotypes with phenotyping beyond the EHR to reveal immunogenetic influences on common health outcomes. They also point to immediate translational avenues - particularly for drug hypersensitivity - while motivating future functional studies and prospective clinical validation to refine mechanistic understanding and clinical utility.