Prospective Registry and Meta‐Analysis of Particle Therapy for Hepatocellular Carcinoma: Clinical Outcomes and Real‐World Impact

A prospective registry study and meta-analysis indicated that particle therapy is a better treatment modality than SBRT for large HCC. Particle therapy and SBRT gave similar outcomes for small HCC. These findings contributed to the adoption of particle therapy for tumors ≥ 4 cm under Japan's national health insurance, highlighting its real-world impact.