Perinatal exposure to delta-9-tetrahydrocannabinol (THC) alters goal-directed behavior and dopamine functioning in wistar rats

These results suggest perinatal exposure to THC can decrease motivation to work for reinforcers during high-effort tasks, that this effect may be more pronounced in males, and that the "amotivational state" resulting from perinatal THC exposure may be due to reinforcer devaluation.