Markers of severe fibrosis in chronic pancreatitis and long-term postoperative outcomes in patients with chronic pancreatitis

Markers of severe pancreatic fibrosis are duration of disease and number of typical CT changes (amount of calcinates, signs of pancreatic atrophy, dilation of the main pancreatic duct). Frey procedure and distal pancreatectomy in patients with chronic pancreatitis and pain syndrome can reduce its intensity in long-term period, stabilize exocrine and endocrine functions of the pancreas. Pain relief did not depend on severity of fibrosis diagnosed by CT and verified by morphological examination of pancreatic tissue.