Pharmacological and Genetic Targeting of Inflammatory Chemokine Receptors CCR1, CCR2, and CCR5 in Atherosclerosis: A Systematic Review and Meta‐Analysis of Preclinical Studies

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Authors

Mohsen Shoaran · University of Glasgow

Elisabetta Caiazzo · University of Naples Federico II

Moustafa I Morsy · University of Glasgow

Danila Gurgone · University of Naples Federico II

Neil MacRitchie · University of Glasgow

Dario Bruzzese · University of Naples Federico II

Armando Ialenti

Abstract

Our analysis suggests that inhibition of either CCR2 or CCR5 is protective in experimental atherosclerosis, while the effect of CCR1 intervention is less clear with potential beneficial effects in male populations.

Topics & Keywords

Chemokine receptors and signaling Atherosclerosis and Cardiovascular Diseases Adipokines, Inflammation, and Metabolic Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of the American Heart Association

Volume 15, Issue 5, pp. e041983-e041983

DOI: 10.1161/jaha.125.041983

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