Abstract PS3-01-07: Advancing Risk-Informed Breast Cancer Screening: Development of a Digital Toolkit for Primary Care and OB/GYN Integration

Abstract Background: Despite strong evidence supporting risk-informed breast cancer screening, implementation in primary care and OB/GYN settings remains limited. Barriers include lack of awareness, clinical time constraints, and inconsistent workflows for identifying and managing at-risk individuals. To address these challenges, the American Cancer Society National Breast Cancer Roundtable (ACS NBCRT) developed a digital Breast Cancer Risk Assessment Toolkit to support frontline providers in initiating, conducting, and acting on breast cancer risk assessment during routine care. Methods: The toolkit was developed over a 12-month period through a collaborative process led by the ACS NBCRT Early Action Priority Team and a national Advisory Group of experts in primary care, breast oncology, health equity, genetics, and public health. The group identified key barriers to implementation and defined practical tools needed to support guideline-concordant care. The resulting toolkit includes:1.Provider communication scripts2.Clinical workflow diagrams3.A risk assessment checklist4.A health system readiness assessment5.A comparison matrix of risk models6.Case studies from academic and community-based settingsContent was reviewed by ACS subject matter experts and aligned with ACS screening guidelines, while acknowledging variation in NCCN and USPSTF recommendations. Tools were designed to support both standalone and team-based care models, with consideration for feasibility in underserved and FQHC settings. Results: Toolkit reviewers—including clinicians and implementation scientists—reported high usability and clinical relevance. The materials supported patient-centered communication, flexible integration into EHR workflows, and strategic decision-making about referrals for genetic counseling or supplemental screening. Case studies highlighted implementation successes from both academic centers and bilingual, community-engaged programs serving Latina women. The model comparison table further supports providers in choosing risk tools that align with their population and system capabilities. Conclusions: The ACS NBCRT Risk Assessment Digital Toolkit offers a novel, digital-first approach to operationalizing breast cancer risk assessment in primary care and women’s health. By providing a streamlined, equity-informed package of tools, the initiative aims to improve early identification of high-risk individuals and expand access to personalized screening and prevention. Future directions include expansion of the case study library to feature additional models from rural and safety-net settings, as well as pilot testing the toolkit through practice-based dissemination and implementation research with primary care and OB/GYN users to assess feasibility, acceptability, and impact on clinical workflows. This scalable resource addresses a long-standing implementation gap and supports broad uptake of risk-informed breast cancer care. Citation Format: M. Thomas, A. Woodworth, A. Hazra, Y. Duron, J. Miller, A. Patel, C. Allen, L. Schlager, L. Soltani, L. Meier. Advancing Risk-Informed Breast Cancer Screening: Development of a Digital Toolkit for Primary Care and OB/GYN Integration [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS3-01-07.