Synthesis of Novel Benzoxazole Derivatives and Study of their Anticancer Activity

The cyclization of Schiff’s bases 2-(6-methoxy-2-naphthyl) methylene] amino} phenol derivatives using Iodobenzoxydi acetate (IBD)/Lead tetra acetate (LTA) to yield 2-(6-methoxy-2-napthyl)-1,3-benzoxazole derivatives 3a-f is achieved. IBD is the most efficient and effective and acts as oxidant in the synthesis of target molecules with better yield than LTA. The obtained products have been characterized by IR, 1H NMR, 13C NMR and Mass spectral studies. The anticancer activity revealed that the compounds 3a, 3c, 3d and 3f were the most active compounds in the series towards HT-29- Human colorectal adenocarcinoma cell line by total lysis with minimum concentration and supported by in silico molecular docking studies.