Design and analysis of randomized clinical trials for onchocerciasis, loiasis and mansonellosis: A systematic review

Several trials were well-planned with detailed information provided in either the manuscript or the registry. However, for some trials, information was sparse or incomplete, indicating a need for more structured and transparent reporting. Adopting established frameworks such as CONSORT and ICH E9 (R1) estimand approach would enhance transparency and better align trial objectives, analyses, and reported conclusions.