Abstract PS1-02-25: Multimodal Exercise in Breast Cancer: Health Impact and Efficacy of Online Modalities. RCT

Abstract Multimodal Exercise in Breast Cancer: Health Impact and Efficacy of Online Modalities. RCTIntroduction Exercise is widely recognized for its significant benefits in cancer survivors, helping improve cardiorespiratory fitness (CRF), reduce fatigue, and positively impact body composition. These advantages are crucial as cancer treatments often lead to reduced physical function and increased fatigue, negatively affecting quality of life (1,2). While traditional supervised exercise programs are effective, access remains a challenge due to logistical barriers. Therefore, exploring remote exercise options is essential for broader accessibility (3,4). This study evaluated the effectiveness and feasibility of a 16-week multimodal exercise intervention comparing online and onsite formats for breast cancer survivors at stages IA to IIIB. Methodology The study was conducted as a randomized controlled trial with 83 participants divided into intervention and control groups. The intervention group was further split into online and onsite subgroups, participating in aerobic, strength, and flexibility exercises. The primary outcomes measured were CRF (using the Bruce test) and body composition (via bioelectrical impedance). Secondary outcomes included functional capacity (sit-to-stand and 6-minute walk tests) and quality of life. Results demonstrated a 22.4% improvement in CRF in the intervention group versus a 4.96% decrease in the control group. Functional capacity also improved significantly in both the online and onsite groups, showing the potential of remote programs to match in-person results (5,6). Body composition changes included a 5.24% increase in lean mass and a 10% decrease in fat mass, supporting evidence that exercise contributes to improved metabolic profiles and lower inflammation, reducing long-term cancer risks (7,8). Conclusions The discussion highlighted a high adherence rate of 95.3% across both modalities, underscoring the effectiveness of flexible delivery for maintaining engagement. The perfect adherence in the online group (100%) emphasized the potential for virtual programs to fit into patients' lives, especially for those balancing responsibilities or facing geographic limitations (9). Limitations included the use of the Borg scale for intensity monitoring instead of more objective measures, suggesting future studies should include precise tools and examine active treatment phases (10).In conclusion, both online and in-person multimodal exercise interventions were effective in enhancing CRF, body composition, and functional capacity in breast cancer survivors. The innovative aspect of demonstrating equivalent results between modalities highlights the potential of flexible, personalized programs to improve access and adherence, ultimately influencing long-term survival and quality of life. Citation Format: S. Casla, M. Castellanos-Montealegre, L. Cantero, M. Ayuso-Chico, J. Haro, Ejercicio y Cáncer. Multimodal Exercise in Breast Cancer: Health Impact and Efficacy of Online Modalities. RCT [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS1-02-25.