A cross-sectional survey on the usage, preference, and clinical experience of pediatricians with cefpodoxime in pediatric infections

Background: Cefpodoxime is frequently prescribed for pediatric bacterial infections; however, real-world insights into its usage patterns, preference, and clinical experience among pediatricians in India are limited. This study evaluated the prescribing trends, perceived efficacy, palatability, safety, and overall satisfaction with cefpodoxime in pediatric practice. Methods: A cross-sectional survey was conducted among pediatricians attending the National Pedicon Conference 2026 using a structured questionnaire. Data on demographics, indications, comparative preference with other β-lactam antibiotics, clinical efficacy, palatability-associated compliance, safety, and satisfaction were collected from 300 respondents. Results: Among 300 pediatricians, 69.7% were male and 31.0% female, with a mean age of 44.58±13.07 years. Cefpodoxime was most prescribed for lower respiratory tract infections (n=206), followed by pharyngitis/tonsillitis (n=186), acute otitis media (n=185), skin and soft tissue infections (n=67), and urinary tract infections (n=57). Across respiratory tract infections, cefpodoxime was consistently preferred over cefpodoxime–clavulanate and other β-lactam antibiotics. Clinical efficacy was rated as excellent by 199 respondents and good by 97, reflecting strong confidence in treatment outcomes. Palatability was reported to significantly improve pediatric patient compliance by 239 pediatricians, while 250 identified palatability as a key determinant of patient satisfaction. In terms of safety, 261 respondents reported no observed adverse events. Overall satisfaction was high, with 188 pediatricians being very satisfied and 107 satisfied with cefpodoxime use. Conclusions: The survey highlights cefpodoxime as a preferred, effective, and well-tolerated antibiotic with added benefits of palatability-driven compliance in pediatric infections.