Oncolytic zika virus therapy leverages CCR2+ monocytes to boost anti-glioblastoma T cell responses

20260 citationsJournal Article

Authors

Kevin S Cashman · University of Louisville

Akshitkumar M. Mistry · University of Louisville

Ashwani Kesarwani · Washington University in St. Louis

Amanda De Andrade Costa · Washington University in St. Louis

Jonah C. Daneshmand · University of Louisville

Hammad Ur Rehman · University of Louisville

Matthias Mack

Abstract

ZIKV-driven activation and recruitment of CCR2+ monocytes supports robust anti-tumor CD8+ T cell responses by enhancing cytotoxicity and limiting exhaustion. These findings highlight the previously unappreciated therapeutic potential of modulating monocyte-T cell crosstalk to overcome immune suppression in GBM.

Topics & Keywords

Mosquito-borne diseases and control Virus-based gene therapy research CAR-T cell therapy research

Publication Details

Published in: Neuro-Oncology

DOI: 10.1093/neuonc/noag037

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Oncolytic zika virus therapy leverages CCR2+ monocytes to boost anti-glioblastoma T cell responses

Authors

Abstract

Topics & Keywords

Publication Details