Refractory Tunnel Infections Caused by Multidrug-Resistant Mycobacterium abscessus Requiring Peritoneal Dialysis Catheter Removal

Tunnel infections (TI) remain a challenging peritoneal dialysis (PD) complication, particularly when caused by <i>Mycobacterium abscessus</i> (<i>M. abscessus</i>). <i>M. abscessus</i> often exhibits multidrug resistance and frequently causes PD catheter removal. We report a case of TI due to multidrug-resistant <i>M. abscessus</i> that failed to respond to antimicrobial therapy and required catheter removal. A 58‑year‑old man on PD for end‑stage renal disease (ESRD) presented with localized abdominal tenderness and erythema with purulent discharge along the PD catheter tunnel tract. Levofloxacin (LVFX) was initiated empirically. <i>M. abscessus</i> was isolated on day 4, and susceptibility testing on day 12 revealed multidrug resistance to antimicrobial therapy, including antituberculosis agents. Despite continued antimicrobial therapy, the infection persisted, and the catheter was removed on day 14. The patient subsequently transitioned to hemodialysis and recovered uneventfully. An optimal therapeutic strategy for TI has not yet been clearly established in current clinical guidelines. In this case, the removal of the PD catheter two days after confirmation of multidrug resistance likely contributed to treatment success. In case of <i>M. abscessus</i>-related TI, prompt catheter removal should be considered as one of the treatment options.