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This chapter provides an overview of major tropical infections encountered in both endemic regions and increasingly in nontropical settings. It reviews the epidemiology, pathophysiology, and clinical course of major tropical infections, including vector-borne, zoonotic, parasitic, and emerging viral diseases, with attention to regional variation and changing patterns driven by urbanization, travel, and climate change. Sections focus on transmission, incubation periods, symptoms, red flags, and diagnostic tests such as rapid tests and polymerase chain reaction (PCR) and outcomes including recurrence and long-term complications. Prevention and treatment options including vaccines and chemoprophylaxis are highlighted. Guidance is provided on risk stratification, including interpretation of medical evidence, and the handling of past infection versus ongoing risk (e.g., latent infections). Focus is on exposure timelines, recurrent episodes, organ damage, and postinfectious sequelae to be anticipated that influence risk assessment for life and health as well as travel and health insurance products.