MiR-34a deficiency enhances nucleic acid sensing and type I IFN signaling in a mouse model of Alzheimer’s disease

20260 citationsJournal Articlegold Open Access

Authors

Jie Yang · Illinois College

George E. Tsourdinis · Illinois College

Charlotte Holas · Illinois College

Mark Maienschein‐Cline · University of Illinois Chicago

Robert Lalonde · Stress, immunité, pathogènes

Ken-ichiro Fukuchi · Illinois College

Abstract

Our results suggest that miR-34a inhibits the transition of microglia to the IRM state that may modulate synaptic and cognitive functions in neurodegenerative diseases and aging.

Topics & Keywords

MicroRNA in disease regulation Neuroinflammation and Neurodegeneration Mechanisms Genomics, phytochemicals, and oxidative stress

Publication Details

Published in: Frontiers in Immunology

Volume 17, pp. 1694824-1694824

DOI: 10.3389/fimmu.2026.1694824

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MiR-34a deficiency enhances nucleic acid sensing and type I IFN signaling in a mouse model of Alzheimer’s disease

Authors

Abstract

Topics & Keywords

Publication Details