Assessing Aβ‐independent effects of Module 42 on immune function in vitro

20260 citationsJournal Articlehybrid Open Access

Authors

Ishita Ajith · Discovery Centre

Souvika Bakshi · Discovery Centre

Emma Mead · Discovery Centre

Opher Gileadi · Karolinska University Hospital

V.L. Katis · Discovery Centre

Paul E. Brennan · Discovery Centre

Katerina Gospodinova ·

Abstract

We tested M42 proteins for their effects on immune functions in vitro. Five proteins altered phagocytosis, and seven altered Ca<sup>2+</sup> signaling. MDK and TMEFF2 ectodomain had an effect on both phagocytosis and Ca<sup>2+</sup> signaling.

Topics & Keywords

Phagocytosis and Immune Regulation Calcium signaling and nucleotide metabolism Endoplasmic Reticulum Stress and Disease

Publication Details

Published in: Alzheimer s & Dementia

Volume 22, Issue 2, pp. e71215-e71215

DOI: 10.1002/alz.71215

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Assessing Aβ‐independent effects of Module 42 on immune function in vitro

Authors

Abstract

Topics & Keywords

Publication Details