Klotho in the kidney distal convolution regulates urinary Klotho excretion and kidney calcium reabsorption, but not phosphate homeostasis

20260 citationsJournal Articlehybrid Open Access

Authors

Laurent Bourqui · Zurich Insurance Group (Switzerland)

Adisa Trnjanin · University of Zurich

Klaudia Kopper · Zurich Insurance Group (Switzerland)

Dominique Loffing‐Cueni · University of Zurich

Zsuzsa Radványi · Zurich Insurance Group (Switzerland)

Artyom Karpovich · University of Zurich

Tara Rahimi

Abstract

DC-derived Klotho regulates urinary sKlotho levels and controls calcium ion reabsorption, while Klotho in proximal tubule maintains phosphate homeostasis and likely regulates circulating sKlotho levels.

Topics & Keywords

Parathyroid Disorders and Treatments Chronic Kidney Disease and Diabetes Kidney Stones and Urolithiasis Treatments

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Kidney International

DOI: 10.1016/j.kint.2026.01.030

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