Quantifying Slowness in Parkinson Disease Using a Serious Game: Cross-Sectional Study

This study proposes a new method to assess slowness in PD by using inertial sensor data to extract objective motor measures (RT and AV) during a serious game, allowing continuous and quantitative evaluation beyond traditional clinical scales and tests. The findings demonstrate that RT and AV extracted from gameplay can detect slowness-related motor differences, supporting the RehaBEElitation serious game as an alternative and objective digital biomarker, with potential applications in both clinical and home-based monitoring of symptom progression.