Considerations in the Use of Mouse Models of Vascular and Valvular Calcification

Murine models of cardiovascular calcification described herein have contributed substantially to our understanding of cardiovascular calcification though the translation toward clinically impactful therapies has, thus far, been limited. Improving clinical translation demands the use of models that replicate human comorbidities, disease progression, and outcomes. Further development of improved models, particularly those that demonstrate clinically important features such as plaque rupture, will facilitate effective translation of therapeutic strategies to clinical practice.