The study of neutrophils to lymphocyte ratio in moderately controlled diabetes (HbA1c 7-9) and its correlation with microvascular complications

Background: The study of neutrophils to lymphocyte ratio in moderately controlled diabetes (HbA1c 7-9) and its correlation with microvascular complications are to measure neutrophil lymphocyte ratio in patients with moderately controlled type 2 diabetes mellitus and to determine the correlation between neutrophil lymphocyte ratio and microvascular complications in moderately controlled type 2 diabetes patients. Methods: Prospective, cross-sectional study, carried out on the patients with type 2 diabetes mellitus patients with hba1c levels 7 to 9, who are attending medicine opd and admitted under medicine. Complete blood count, fundoscopy, urine microalbumin and monofilament were analysed in these patients. Results: This study shows that more than half (63%) of the study participants were males and 37% were females. Most of the patients came for follow up (81%). In our study it was observed that patient with microvascular complications like retinopathy, nephropathy and neuropathy had higher NLR when compared with patients with no microvascular complications. Conclusions: Our study revealed that NLR was significantly raised in T2DM patients with microvascular complications. NLR being a simple, cost effective and easily available investigation can be used for screening tool to detect diabetic micro complications at an earliest especially in a resource constrained setup with limited laboratory facilities. Hence, NLR can be considered as a potential alternative for other costlier inflammatory markers and also a prognostic biomarker of any microvascular complications among T2DM patients.