Myeloid KIF13B suppresses the STT3A/CTSD/THBS1 axis to prevent MASH

20260 citationsJournal Article

Authors

Kaikai Lu · Peking University

Xianqin Shen · Peking University

Ziyang Guo · Peking University

Jie Chen · Peking University

Lei He · Peking University

Aiden Xian · Plano Cancer Institute

Si Mei · Peking University

Abstract

Collectively, our study establishes a novel regulatory axis, ZNF384/KIF13B/STT3A/CTSD/THBS1, essential for macrophage-hepatocyte crosstalk during MASLD progression and provides potential therapeutic targets for the treatment of MASLD.

Topics & Keywords

Genomics and Rare Diseases interferon and immune responses Fibroblast Growth Factor Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

DOI: 10.1097/hep.0000000000001726

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