Characterizing Longitudinal Molecular Changes in ctDNA in Patients with Metastatic Castration-resistant Prostate Cancer

20260 citationsJournal Article

Authors

Chinmay Jani · Sylvester Comprehensive Cancer Center

Eli Tran · University of California San Diego

Nicole Zhang · Guardant (United States)

Jill Tsai · Guardant (United States)

Jianjie Dong · Scripps Research Institute

Mrs Leslie Bucheit · Guardant (United States)

Elizabeth Pan

Abstract

Our study revealed dynamic shifts in genetic mutations in patients with mCRPC following ARPI, PARPi and taxanes. Furthermore, our findings highlight associations between AR alterations and clinical outcomes, emphasizing the potential for personalized treatment strategies.

Topics & Keywords

Prostate Cancer Treatment and Research Prostate Cancer Diagnosis and Treatment Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-25-3071

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