DPP4 inhibition affects metabolism and inflammation associated pathways in hiPSC-derived steatotic HLCs

20261 citationsJournal Articlegold Open Access

Authors

Christiane Loerch · Düsseldorf University Hospital

Wasco Wruck · Düsseldorf University Hospital

Annika Wittich · Fraunhofer Institute for Translational Medicine and Pharmacology

Rabea Hokamp · Düsseldorf University Hospital

Julian Reiss · Düsseldorf University Hospital

Ole Pleß · Fraunhofer Institute for Translational Medicine and Pharmacology

James Adjaye

Abstract

Given the difficulties of identifying suitable anti-MAFLD drugs, novel model systems are urgently needed. Our <i>in vitro</i> HLC-model reproduced the DPP4-dependent aspects of the disease and responded positively to VILDA treatment. Further elucidation of the role of DPP4 in the etiology of MAFLD and other diseases is warranted.

Topics & Keywords

Peptidase Inhibition and Analysis Pancreatic function and diabetes Liver Disease Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Cell and Developmental Biology

Volume 14, pp. 1686556-1686556

DOI: 10.3389/fcell.2026.1686556

Field-Weighted Citation Impact: 24.25