Binaural Beat Stimulation Enhances Cognitive Function in Alzheimer’s Disease via Temporal Lobe Activation: An sLORETA Study

<b>Background</b>: The global prevalence of Alzheimer's disease (AD) has reached 55.2 million. AD is characterized by progressive deterioration in cognition and working memory (WM), which are essential for attention, reasoning, and learning. These impairments are associated with pathological changes in cortical and subcortical regions. Binaural beats (BBs), a non-invasive auditory neuromodulation technique, have demonstrated cognitive enhancement effects in healthy individuals; however, their impact on WM in patients with AD remains largely unexplored. <b>Methods</b>: This study investigated the effects of BB stimulation on WM and cognitive function in the temporal lobe of patients with AD using standardized Low-Resolution Electromagnetic Tomography (sLORETA). Twenty-five patients with AD were randomly assigned to either an experimental group (<i>n</i> = 15) that received BB stimulation or a control group (<i>n</i> = 10) that received standard auditory stimulation. EEG recordings were obtained before and after the intervention. <b>Results</b>: Paired <i>t</i>-tests conducted on timeframe and frequency-wise sLORETA images revealed significant increases (<i>p</i> < 0.05) in theta, alpha1, and alpha2 frequency bands in the experimental group. Activated regions included the inferior, middle, superior, and transverse temporal gyri; Brodmann areas (BA) 20, 21, 22, 40, and 42; as well as networks associated with working memory and cognition. <b>Conclusions</b>: These findings suggest that BB stimulation induces temporal lobe activation, thereby enhancing working memory and cognitive function in patients with AD.