Determinants of fatal outcome in septic shock patients with euthyroid sick syndrome

The 28-day mortality among patients with septic shock and ESS was 52%. Duration of mechanical ventilation, ICU stay, severity scores, laboratory parameters, and indices such as SI and mGPS were significantly associated with outcome. The presence of ESS may contribute to adverse prognosis, and combined evaluation of clinical and laboratory factors can improve risk stratification in this high-risk population.