Ultra-low Concentrations of Cisplatinum Down to the IC ₁₀ in Combination With Recombinant Methioninase Are Synergistically Effective Against Lung Cancer Cells <i>In Vitro</i> and <i>In Vivo</i>

Methionine restriction enhances the efficacy of ultra-low-dose cisplatinum on lung cancer cells <i>in vitro</i>. Low-dose cisplatinum in combination with an MR diet prevented lung-cancer growth in nude mice. The present approach of cancer therapy may help reduce platinum-related toxicity and improve treatment outcomes, suggesting further investigation for clinical translation.