CryoEM-BAG France: Structural biology using cryoEM in France

This proposal gathers Principal Investigators from Institutes across France that use cryoEM to unravel the molecular mechanisms associated with different fundamental biological processes. Scientists belong to 12 centres that currently use CM01 for cryoEM. PIs in this application were part of the previous BAG MX2596, with one new member who has previously used CM01 via rolling access, replacing two members who have left. For the next 6 month period we have asked for the same number of shifts as awarded for 2024/4 (48 shifts). Over 18 projects from the BAG are ready for data collection at ESRF CM01. These include the study of bacterial and viral infection machineries (Bordeaux, Lyon, Paris, Marseille), translational and trancriptional control mechanisms (Bordeaux, Toulouse, Paris, Strasbourg), structural proteins involved in muscle or macromolecular transport (Bordeaux, Lyon, Strasbourg, Paris), and enzymes (Paris, Bordeaux, Toulouse).