EZH2 Expression Is Associated With Sensitivity to Inhibitors and Promotes Malignancy in Endometrial Cancer Cells

20260 citationsJournal Article

Authors

TAKAFUMI ONISHI · Kyoto Tachibana University

HIROYA NIIMI · Aichi Medical University Hospital

Aya Kumazaki · Kyoto Tachibana University

Yuto Masaki · Kyoto Tachibana University

SHOMA NOMURA · Otsu Municipal Hospital

Hirokazu Odashima · Kyoto Tachibana University

Yukihiko Osawa ·

Abstract

EZH2 plays a crucial role in promoting malignant phenotypes in EC, and its expression level correlates with cellular sensitivity to EZH2 inhibitors. These findings suggest that EZH2 could serve as a valuable therapeutic target and predictive biomarker for personalized medicine in EC.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related gene regulation Genomics and Chromatin Dynamics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anticancer Research

Volume 46, Issue 3, pp. 1259-1269

DOI: 10.21873/anticanres.18027

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