Second-Generation Aldosterone Synthase Inhibitors for Hypertension

20260 citationsJournal Articlediamond Open Access

Authors

Flávia Queiroga · Emory University

Beatriz Barbosa Cruz Soares Araújo · Universidade Nove de Julho

André Rivera · Universidade Nove de Julho

Letizia Consoli · Universidade Federal da Bahia

Aditi Ujjawal · Beth Israel Deaconess Medical Center

Ensieh Sadat Mansouri · Iran University of Medical Sciences

Maria Antônia Costa Cruz Akabane

Abstract

Second-generation ASIs had a high likelihood of a clinically significant reduction in SBP compared with placebo. However, hyperkalemia, hyponatremia, and hypotension were more frequent with ASIs.

Topics & Keywords

Hormonal Regulation and Hypertension Renin-Angiotensin System Studies Ion Transport and Channel Regulation

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: JACC Advances

Volume 5, Issue 3, pp. 102621-102621

DOI: 10.1016/j.jacadv.2026.102621

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