FAS/FAS-ligand Apoptotic Complex Deregulation in Laryngeal Squamous Cell Carcinomas

20260 citationsJournal Article

Authors

Michail Athanasopoulos · General University Hospital of Patras

Vasileios Papanikolaou · Sotiria General Hospital

Dimitrios Roukas · NIMTS Hospital

Aristeidis Chrysovergis · General Hospital of Athens Elpis

Georgios PAPANASTASIOU · University of Ioannina

Maria Adamopoulou · The American College of Greece

Ioanna E METAXAS

Abstract

FAS/FAS-L apoptotic system deregulation is a relatively frequent event in LSCCs. Dysregulation of the system - due to altered FAS and FAS-L co-expression levels - negatively affects the normal apoptotic mechanism. Additionally, this abnormality is clearly observed in aggressive phenotypes (advanced stage, enlarged tumor volume).

Topics & Keywords

Cell death mechanisms and regulation Ubiquitin and proteasome pathways S100 Proteins and Annexins

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anticancer Research

Volume 46, Issue 3, pp. 1421-1428

DOI: 10.21873/anticanres.18038

Field-Weighted Citation Impact: 0.00