Self-reported late effects, daily functioning, and health-related quality of life in older Hodgkin lymphoma survivors – a national population-based cross-sectional survey

In a Norwegian national cross-sectional survey, we assessed the burden of selected late effects (LEs) by a 95-item questionnaire in tumor-free Hodgkin lymphoma survivors (HLSs) diagnosed at age ≥60 years. Responses were compared to age- and sex-matched controls. A total of 290 older HLSs diagnosed 2000-2021 received the questionnaire, 193 (67%) were included. Median age at survey was 76 years (range 63-92) and median time since diagnosis 7 years (2-23). Compared to controls, HLSs reported significantly higher rates of heart failure (10% <i>vs.</i> 6%), atrial fibrillation (19% <i>vs.</i> 14%), memory problems (48% <i>vs.</i> 37%), other cognitive difficulties (34% <i>vs</i>. 17%) and chronic fatigue (29% <i>vs</i>. 13%). HLSs scored lower on physical and mental health-related quality of life (HRQoL) and more often reported needing help with basic (P-ADL) and instrumental activities of daily living (I-ADL). However, differences were small, only for fatigue and dependence in I-ADL did the difference reach moderate statistical effect size.