Understanding the Impacts and Science Behind Disinfectant Residue

EU GMP Annex I, Section 4.36 specifically states that "Cleaning programs should effectively remove disinfectant residues". Although residue in controlled environments, and disinfectant residue in particular, has been around since the advent of cleanroom disinfection, there is currently an increased sensitivity towards understanding and mitigating cleanroom residues.This talk will focus on the science and microbiology of scientific residues including potential impact on rotational sporicides, the likelihood of trapping microorganisms and best practices for addressing residue in the cleanroom. The active ingredients and surfactants that make up disinfectant residue are not inherently bad, but instead key components of a complex formulation. By understanding the nature of disinfectant residue and their impacts, continuous improvements can be made to optimize an overall cleaning and disinfection program.