Hepatocyte growth factor may contribute to male protection against pulmonary arterial hypertension

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Authors

Lejla Medzikovic · University of California, Los Angeles

Grégoire Ruffenach · Inserm

Ateyeh Dehghanitafti · University of California, Los Angeles

Brenda Wong · University of California, Los Angeles

Ashley Ryder · University of California, Los Angeles

Mohammad Reza Hatamnejad · University of California, Los Angeles

Wasila Sun

Abstract

Lung HGF expression may be upregulated to counteract PAH disease progression by inhibiting proliferation of PASMC and PAFB. Elevated HGF in males might at least partially account for the lower incidence of male PAH patients.

Topics & Keywords

Pulmonary Hypertension Research and Treatments Liver physiology and pathology Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Biology of Sex Differences

DOI: 10.1186/s13293-026-00852-6

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