Search for a command to run...
Abstract Artificial intelligence (AI), particularly large language models (LLMs), is increasingly explored in healthcare, yet its real-world usability and safety in high-risk clinical pharmacy tasks remain uncertain. Vancomycin therapeutic drug monitoring (TDM), which requires precise pharmacokinetic calculations and context-sensitive interpretation within a narrow therapeutic window, provides a stringent test case for AI-assisted decision support. This proof-of-concept study developed and evaluated a hybrid clinical decision support system (TDM-AID) integrating a validated deterministic pharmacokinetic calculation engine, GPT-4o–based structured clinical interpretation, and retrieval-augmented guideline support. Thirty retrospective adult vancomycin TDM cases were assessed using a weighted six-domain rubric covering pharmacokinetic accuracy, AUC estimation, prospective prediction, timing recommendations, clinical judgment, and documentation quality. Two independent expert pharmacists evaluated system outputs against benchmark consultations. The overall median performance was 78% (IQR 12%), classified as Acceptable, and 73% (IQR 14%) when deterministic calculations were excluded. Foundational pharmacokinetic calculations achieved 100% accuracy. Clinical judgment demonstrated Good performance (83%), whereas prospective prediction was limited (58%), and timing recommendations were absent in all cases. Safety violations occurred in 17% of cases, including dose recommendations exceeding 4 g/day. Inter-rater reliability was good (ICC 0.87). These findings suggest that hybrid AI-driven decision support is technically feasible and usable as a pharmacist-augmenting draft generator; however, limitations in predictive reasoning, timing logistics, and safety enforcement necessitate deterministic safeguards and mandatory expert oversight before clinical implementation.