Injectable dual-drug hydrogel containing curcumin and glycyrrhizic acid for biofilm inhibition and immunomodulatory therapy in periodontitis

This study presents an injectable dual-drug hydrogel, CURM@GLH, that integrates biofilm inhibition with immunomodulatory regulation, offering a promising host-directed therapeutic strategy for periodontitis. The proposed approach provides new insights into the design of multifunctional biomaterials for the treatment of chronic inflammatory diseases associated with biofilm persistence and immune imbalance.