Excessive Anesthetic Depth Is Associated With Increased Rate of Postoperative Delirium After Cardiac Surgery: A Retrospective Analysis of Processed Electroencephalography

Exposure below the recommended anesthetic depth threshold (PSI of 25), measured by both duration and cumulative area, was a significant risk factor for POD after cardiac surgery. These associations persisted even after adjustment for multiple confounders. PSI-guided anesthesia may represent a modifiable intraoperative factor with the potential to reduce the occurrence of POD.