PO:06:153 Serological evolution of autoantibody clusters in systemic lupus erythematosus

Objectives This study evaluates the potential of large language models (LLMs) in clinical decision-making for atypical presentations of systemic lupus erythematosus (SLE).It assesses their ability to assist with diagnosis, further investigations, and treatment planning.Diagnostic and treatment recommendations from LLMs were compared with those of treating physicians to evaluate performance and reliability.The models used were Claude 3 Opus, GPT-4o Mini, and Gemini 2.0 Flash.Methods A PubMed search identified case reports published after April 2024 to ensure exclusion from model training data.Of 95 studies screened, 24 cases from 23 studies were included, all involving atypical SLE presentations not meeting classification criteria.Exclusion criteria were prior SLE diagnosis, insufficient diagnostic data, or unavailable full texts.Clinical data-symptoms, laboratory and imaging findings, and medical history-were standardized and entered into LLMs for diagnostic, investigative, and therapeutic suggestions.Models operated offline, using internal knowledge.Antinuclear antibody testing was analyzed as an indicator of SLE suspicion.Each model's ability to identify SLE and its ranking in differential diagnoses were assessed.Initial and long-term treatment recommendations were compared with those of treating physicians.Results All three LLMs proposed SLE as a differential in every case.Gemini most often ranked SLE first, while Claude requested ANA more frequently; neither difference was significant.Objectives To evaluate the serological evolution of patients with systemic lupus erythematosus (SLE), focusing on the appearance or modification of existing autoantibodies.Methods A retrospective study was conducted on 82 SLE patients treated at a general hospital in northern Spain.Demographic data, clinical features, comorbidities, treatments, and Abstract PO:06:152 Table 1 Performance comparison of LLMs in diagnostic and treatment decisions for atypical SLE cases