PO:07:189 Clinical and immunoserological profile of SLE patients in Serbia: a two-center cohort analysis

Abstracts1.731.95).Environmental exposures varied significantly; Cluster five showed the highest CO2 emissions and solar irradiance, while Cluster three had the lowest environmental burden.PCA showed that clinical manifestations, disease activity and chronicity were different across clusters.The figure highlights the separation of the characteristics according to the three principal components.Conclusions Socioeconomic and environmental factors at the individual, regional, and national levels influence the cumulative clinical manifestations and patient-reported outcomes in SLE.Our findings underscore the role of social vulnerability and environmental stressors as potential modifiers of SLE phenotype in Latin America, highlighting the need for context-sensitive interventions and policies to mitigate health inequities.