S7:04 Predictors of sustained drug-free remission in systemic lupus erythematosus (SLE). Data from the SLICC (systemic lupus international collaborating clinics) inception cohort

sion signatures known to be elevated in established SLE did not exhibit a decisive role in disease initiation.Flow cytometric IFN analysis suggests that IFN-pathway activation in memory B cells driving plasmablast differentiation is an appropriate set of targets for prevention therapy in high-risk individuals.The reduction in SLE gene expression signatures over time might represent onset of the immune exhaustion known in SLE that, in non-progressors, could be protective. Disease Activity Outcome Measures, andTreat-to-Target