Inhibition of c-FLIP alongside TRAIL treatment suppresses prostate cancer stem cell activity

20260 citationsJournal Articlehybrid Open Access

Authors

Daniel J. Turnham · University of the West of England

Rhiannon French · Cardiff University

Fiona M. Frame · Yorkshire Cancer Research

Valérie S. Méniel · Cardiff University

Norman J. Maitland · Yorkshire Cancer Research

R. Clarkson · Cardiff University

Abstract

Inhibition of cFLIP in combination with either TRAIL or docetaxel has the potential to be used as a novel therapeutic approach to provide more potent, long-lasting benefits to men with prostate cancer.

Topics & Keywords

Cell death mechanisms and regulation PI3K/AKT/mTOR signaling in cancer Endoplasmic Reticulum Stress and Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Cancer

DOI: 10.1038/s41416-026-03359-4

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