Treatment of Venous Leg Ulcers by Cyanoacrylate Glue: a Prospective Study of Safety and Feasibility

Type of Research: Single-center prospective non-randomized feasibility cohort study.Key Findings : Among 38 CEAP C6 patients, cyanoacrylate treatment achieved 90.6% ulcer healing at 12 months, with 81.2% healed by 6 months and no ulcer recurrence.Clinical severity, pain, and quality-of-life scores improved significantly, with no serious glue-related adverse events.Take home Message: A non-thermal cyanoacrylate strategy treating both saphenous reflux and incompetent perforators in a single session is feasible, safe, and associated with rapid healing of active venous leg ulcers, offering a practical alternative to thermal or surgical approaches J o u r n a l P r e -p r o o f Table of Contents SummaryThis single-center prospective feasibility study found that cyanoacrylate closure of the great saphenous vein combined with targeted perforator embolization achieved a 90.6% healing rate at 12 months in patients with active venous leg ulcers.The study suggests this nonthermal, ultrasound-guided approach is a safe and effective alternative to conventional thermal or surgical strategies and may help streamline care and accelerate ulcer healing