Synergistic elastase and papain injury drives abdominal aortic aneurysm formation and rupture in mice

20260 citationsJournal Articlegold Open Access

Authors

Santiago Elizondo-Benedetto · Washington University in St. Louis

Mohamed S. Zaghloul · Washington University in St. Louis

Batool Arif · Washington University in St. Louis

Ibrahim Kuziez · Washington University in St. Louis

Ryan Wahidi · Washington University in St. Louis

Mohamed A. Zayed · Washington University in St. Louis

Abstract

This murine model, using a synergistic combination of pancreatic elastase and papain, effectively replicates AAA pathophysiology and is ideal for investigating underlying mechanisms and potential therapeutic interventions.

Topics & Keywords

Aortic aneurysm repair treatments Infectious Aortic and Vascular Conditions Cardiac, Anesthesia and Surgical Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Communications Medicine

DOI: 10.1038/s43856-026-01485-x

Field-Weighted Citation Impact: 0.00