Uncovering the Untapped Potential of Furosemide in Sepsis: Real-World Evidence on Coagulopathy and Organ Outcomes

Real-world evidence suggests that furosemide use is associated with reduced sepsis-related coagulopathy and favorable organ outcomes. These findings generate a biologically plausible hypothesis consistent with Na +-K +-2Cl - cotransporter 1 (NKCC1)-related antioxidant and anti-inflammatory pathways observed in preclinical models, warranting confirmation in prospective trials.