Transcriptional Control of Hepatocellular Carcinoma Cells Aggressiveness by AAV2/8-Mediated Delivery of Human Centenarian-Associated SIRT6 N308K/A313S

20260 citationsJournal Articlegold Open Access

Authors

Maanya Vittal · Liverpool John Moores University

Niccolò Liorni · Agostino Gemelli University Polyclinic

Ahmed Kazaili · University of Liverpool

Eric Leire · Institute of Pathology and Genetics

Riaz Akhtar · University of Liverpool

Tommaso Mazza · Agostino Gemelli University Polyclinic

Manlio Vinciguerra

Abstract

These data suggest that increased intracellular stiffening mirrors increased cell motility and invasive behavior; it can be indicative of suppressed cancer development and progression by the centenarian-associated SIRT6 N308K/A313S mutant.

Topics & Keywords

Sirtuins and Resveratrol in Medicine Extracellular vesicles in disease Cancer-related molecular mechanisms research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancers

Volume 18, Issue 5, pp. 812-812

DOI: 10.3390/cancers18050812

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