Mesenchymal stem cell-derived miR-125b-1-3p-abundant exosomes alleviate osteoarthritis by modulating the KDM6B-H3K27me3-FOXM1 axis

This study elucidates a novel molecular mechanism through which BMSC-Exos shuttle miR-125b-1-3p to alleviate OA by modulating the KDM6B/H3K27me3/FOXM1 signalling axis. These findings provide a theoretical rationale and identify promising therapeutic targets for the development of exosome-based therapeutic strategies against OA.