Macrophage polarization in immune-inflammatory diseases with lung damage: The promising therapeutic strategies

The article discusses the role of macrophage polarization in the processes of inflammation and fibrosis. Targeting the polarization of alternatively activated M2 macrophages could be a promising strategy to prevent fibrosis progression. The prospects for the treatment of immune-inflammatory diseases with lung damage, aimed at macrophage functions, are considered, including the possibilities of using the selective neuropilin 2 modulator efzophytimod in systemic sclerosis and sarcoidosis, as well as other diseases.